Broad neutralization response in a subset of HIV-1 subtype C-infected viraemic non-progressors from southern India

Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains

Citation: Cheedarla N, Hemalatha B, Anangi B, Muthuramalingam K, Selvachithiram M, Sathyamurthi P, Kailasam N, Varadarajan R, Swaminathan S, Tripathy SP, Vaniambadi SK, Vadakkupattu DR and Hanna LE (2018) Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains. Front. Immunol. 9:618. doi: 10.3389/fimmu.2018.00618 ...

Long term non progressors (LTNP) with vertically infected HIV children - a report from western India

Neutralization of tier-2 viruses and epitope profiling of plasma antibodies from subtype-C HIV-1 infected north Indians; implications for MPER directed HIV-1 neutralization

Methods Plasma of eighty naïve HIV-1 seropositive Indian patients were tested for neutralization against a panel of 3 subtype-B and 5 subtype-C tier 1 and tier 2 viruses. Three plasma, found to be broadly neutralizing (bNP), were mapped with a set of 212 consensus-C gp160 overlapping peptides (15mer each). 50% binding titers were determined by ELISA using consensus-C V3 (35mer), IDR loop (19mer...

Subtype & cytokine profiles of HIV infected individuals from south India.

BACKGROUND & OBJECTIVE The global surveillance of human immunodeficiency virus (HIV) subtypes (clades) helps understand the global distribution and incidence of different HIV subtypes. As knowledge about subtypes circulating in an area is needed for developing a candidate vaccine, prevalence of the subtypes HIV-1 and HIV-2 were studied in south India. The profile of cytokines interleukin 10 (IL...

Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals.

A small proportion of HIV-infected individuals generate a neutralizing antibody (NAb) response of exceptional magnitude and breadth. A detailed analysis of the critical epitopes targeted by broadly neutralizing antibodies should help to define optimal targets for vaccine design. HIV-1-infected subjects with potent cross-reactive serum neutralizing antibodies were identified by assaying sera fro...